In The Last Smoker in America, a dysfunctional family is struggling to survive in a world where smoking has recently been outlawed. Pam is having an impossible time trying to quit. Her husband Ernie dreams of being a rock star and relentlessly practices his electric guitar in the basement. Their teenage son Jimmy listens to so much rap music he’s convinced he’s black, while their nosy, anti-smoking zealot neighbor Phyllis lurks around trying to catch transgressors mid-puff.