Thomas received Academy Award and Golden Globe Award nominations for her performance in The English Patient. Her other film credits include Keeping Mum, Chromophobia, Man to Man, Gosford Park, Life as a House, Up at the Villa, The Tenth Man, Random Hearts, The Horse Whisperer, Angels and Insects for which she received the Evening Standard Award for Best Actress, Richard III, Four Weddings and a Funeral, Bitter Moon, A Handful of Dust for which she received the Evening Standard Award for Best Newcomer and the French films Force Majeure, Le Bal du Gouverneur, Arsène Lupin, La Doublure and Aux Yeux du Monde. In 2001, Thomas, who was trained at the École Nationale des Arts et Technique de Théâtre in Paris, starred in a Paris stage production of Jean Racine's Bérénice. In 2003, she starred in a West End production of Three Sisters. She returned to the London stage last season to star opposite Bob Hoskins in Luigi Pirandello's As You Desire Me.
The Royal Court production of The Seagull will utilize an adaptation by Christopher Hampton, who worked on the version of Three Sisters in which Scott Thomas starred.