The story centers on Roberta Glass, a bored New Jersey housewife who seeks adventure through her obsession with personal ads and the mysterious Susan, a street-smart East Village drifter. When Roberta suffers a bad case of amnesia, she and Susan unexpectedly swap lives and are plunged into a world of jewel heists, magic shows and rock ‘n' roll. The collision of Roberta and Susan's identities takes them on a wild journey of mystery, self-awareness, and true love—with both women discovering that you never know where your life is going, until something magical happens. The film, written by Leora Barish and directed by Susan Seidelman, marked the big screen debut of Madonna, who played the role of Susan. Rosanna Arquette co-starred as Roberta.
Desperately Seeking Susan is being produced by Susan Gallin, Ron Kastner, Mark Rubinstein and Old Vic Productions.