In a statement, Cherry Lane Artistic Director Angelina Fiordellisi said, "Ms. Myra Carter, whom we believe to be brilliant in the role, will be unable to perform due to health issues. It is our hope and wish that she have a speedy recovery." In addition to Markle, the cast includes George Bartenieff as Daddy, Kathleen Butler as Mrs. Barker, Judith Ivey as Mommy, Harmon Walsh as the American Dream, and Jesse Williams as the Angel of Death in The Sandbox.
Markle is an Albee veteran, including productions of Who's Afraid of Virginia Woolf? at Trinity Square Rep, Three Tall Women on a national tour, A Delicate Balance at Arizona Theatre Company and Albee's Women at Old Globe. Markle's Broadway credits include True West, The Grapes of Wrath, A Warm Body and Calculated Risk.