Lancashire is best known for playing Raquel Catherine Watts née Wolstenholme on the television series Coronation Street, on which she appeared for nearly seven years. Her series credits since leaving that show in 1996 include, Bloomin' Marvellous, Where the Heart Is, Clocking Off, Chambers and Rose and Maloney. While she is well known for her television work, Lancashire also has experience on the stage. A graduate of the Guildhall School of Music and Drama, her theatrical credits include productions of Pacific Overtures, The Beauty Game, Blood Brothers, Little Shop of Horrors and Educating Rita.